Understanding changes in the mammalian prenylome induced by statins and prenyltransferase inhibitors

异戊二烯类脂与蛋白质的共价结合是哺乳动物细胞中普遍存在的一种现象。它对蛋白质的正常功能至关重要，它会导致癌症和炎症的进展。我们已经开发了一种新的技术来识别细胞中所有的前烯基化蛋白质。借助这种方法，我们将分析他汀类药物和抗癌药物对蛋白质预烯基化的影响。这将为确定它们更有效的临床使用提供指导。

Prenylation, the covalent attachment of isoprenoid lipids to proteins, is widespread in mammalian cells. Essential for a protein's normal function, it contributes to the progression of cancer and inflammation. We have developed a novel technology to identify all prenylated proteins in the cell. Aided by this method, we will analyse the effect of statins and anti-cancer drugs on protein prenylation. This will provide guidance in identifying a more effective clinical use for them.