Understanding changes in the mammalian prenylome induced by statins and prenyltransferase inhibitors

了解他汀类药物和异戊二烯转移酶抑制剂引起的哺乳动物异戊二烯体的变化

• 批准号: nhmrc : 569652
• 负责人: Daniel Abankwa
• 金额: $ 37.76万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-changes-mammalian-prenyltransferase-inhibitors/98355
• 关键词: Understanding; changes; mammalian; prenylome; induced

Prenylation, the covalent attachment of isoprenoid lipids to proteins, is widespread in mammalian cells. Essential for a protein's normal function, it contributes to the progression of cancer and inflammation. We have developed a novel technology to identify all prenylated proteins in the cell. Aided by this method, we will analyse the effect of statins and anti-cancer drugs on protein prenylation. This will provide guidance in identifying a more effective clinical use for them.

异戊二烯化是类异戊二烯脂质与蛋白质的共价连接，广泛存在于哺乳动物细胞中。它对于蛋白质的正常功能至关重要，它会促进癌症和炎症的进展。我们开发了一种新技术来识别细胞中所有异戊二烯化的蛋白质。借助这种方法，我们将分析他汀类药物和抗癌药物对蛋白质异戊二烯化的影响。这将为确定更有效的临床用途提供指导。