Understanding the contribution of sympathetic overactivity to maternally programmed obesity related hypertension

了解交感神经过度活跃对母体程序性肥胖相关高血压的影响

• 批准号: nhmrc : 1043205
• 负责人: A/Pr James Armitage
• 金额: $ 40.35万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-contribution-sympathetic-related-hypertension/111559
• 关键词: Understanding; contribution; sympathetic; overactivity; maternally

Obesity and associated diseases are increasing worldwide. Aside from adult risk factors, the environment encountered during development may predispose to later disease. Our data shows that the diet consumed by pregnant mothers can influence the development of obesity and hypertension in her offspring and that the sympathetic nervous system becomes dysregulated. This project will assess how maternal fat intake in pregnancy affects sympathetic nervous system function in the offspring and we investigate possible management strategies.

肥胖和相关疾病在世界范围内日益增加。除了成年人的风险因素外，发育过程中遇到的环境可能会导致以后的疾病。我们的数据表明，孕妇的饮食可以影响其后代肥胖和高血压的发展，并且交感神经系统变得失调。本项目将评估母亲在怀孕期间的脂肪摄入如何影响后代的交感神经系统功能，并研究可能的管理策略。