Understanding and controlling remodelling in pulmonary fibrosis and asthma

了解和控制肺纤维化和哮喘的重塑

• 批准号: nhmrc : 509001
• 负责人: Dr Blanca Camoretti-Mercado
• 金额: $ 28.8万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-controlling-remodelling-fibrosis-asthma/95511
• 关键词: Understanding; controlling; remodelling; pulmonary; fibrosis

The development of scar tissue is a normal response to tissue injury. When airway and lung tissue is injured by exposure to irritants, scarring greatly diminishes the function of the lung to allow transfer of oxygen to the tissue. In severe disease, the scarring may be fatal. We discovered that two factors involved in formation of scar tissue neutralise each other's effects. We are examining this interaction in human lung to develop new treatments for scarring-related lung diseases.

疤痕组织的发展是对组织损伤的正常反应。当气道和肺组织因暴露于刺激物而受损时，瘢痕形成会大大降低肺将氧气输送到组织的功能。在严重的疾病中，疤痕可能是致命的。我们发现，两个因素参与形成疤痕组织抵消对方的影响。我们正在研究人类肺部的这种相互作用，以开发瘢痕相关肺部疾病的新疗法。