Understanding epilepsy: from genes to neural circuits

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Epilepsy is common neurological disorder characterised by abnormal brain activity known as seizures. Many patients with epilepsy respond poorly to treatment. A major reason is because it is unknown how abnormalities in single brain cells generate seizures, which involve large numbers of brain cells. This project will tackle this problem using modeling and experimental techniques. A better understanding of how seizure develop in the brain will lead to more effective and targeted therapy.