Understanding epilepsy: from genes to neural circuits

了解癫痫：从基因到神经回路

• 批准号: nhmrc : GNT1168273
• 金额: $ 4.66万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-epilepsy-genes-neural-circuits/1379450
• 关键词: Understanding; epilepsy; genes; neural; circuits

Epilepsy is common neurological disorder characterised by abnormal brain activity known as seizures. Many patients with epilepsy respond poorly to treatment. A major reason is because it is unknown how abnormalities in single brain cells generate seizures, which involve large numbers of brain cells. This project will tackle this problem using modeling and experimental techniques. A better understanding of how seizure develop in the brain will lead to more effective and targeted therapy.

癫痫是一种常见的神经系统疾病，其特征是被称为癫痫发作的异常大脑活动。许多癫痫患者对治疗反应不佳。一个主要原因是，目前尚不清楚单个脑细胞的异常如何导致癫痫发作，而癫痫发作涉及大量脑细胞。这个项目将使用建模和实验技术来解决这个问题。更好地了解癫痫如何在大脑中发展将导致更有效和有针对性的治疗。