Understanding local and regional determinants of EDHF and NO dysfunction in resistance arteries in diabetes

了解糖尿病患者阻力动脉 EDHF 和 NO 功能障碍的局部和区域决定因素

• 批准号: nhmrc : 546087
• 负责人: A/Pr Shaun Sandow
• 金额: $ 51.43万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-local-regional-arteries-diabetes/81930
• 关键词: Understanding; local; regional; determinants; EDHF

Diabetes is a serious and increasing health burden worldwide. Most of the sickness and death associated is due to complications arising in the blood vessels. The inner lining of blood vessels in small arteries uses several different mechanisms to ensure proper blood flow, and in diabetes these are impaired. This study will reveal the cellular mechanisms involved and identify pathways for therapeutic intervention to alleviate the debilitating effects of small artery disease.

糖尿病是世界范围内一个严重且日益严重的健康负担。大多数相关的疾病和死亡是由于血管并发症引起的。小动脉中的血管内层使用几种不同的机制来确保适当的血液流动，而在糖尿病患者，这些机制受到了损害。这项研究将揭示相关的细胞机制，并确定治疗干预的途径，以减轻小动脉疾病的衰弱效应。