Understanding novel viral host interactions that modulate innate immunity

了解调节先天免疫的新型病毒宿主相互作用

• 批准号: nhmrc : 2003636
• 金额: $ 76.42万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/understanding-novel-viral-innate-immunity/1780179
• 关键词: Understanding; novel; viral; host; interactions

Lethal viruses such as coronaviruses (MERS, SARS-CoV-1, SARS-CoV-2), Dengue, Zika, Hendra, and Nipah have developed effective mechanisms of replication by dampening the host immune system. Here we will examine how viruses carry out these immune evasion functions, and test antiviral drugs that can prevent these effects in a highly specific manner. If this idea can be proved, it will provide great promise for the development of new antivirals whilst minimising the toxic effects to the cell.

冠状病毒（中东呼吸综合征、SARS-CoV-1、SARS-CoV-2）、登革热、寨卡病毒、亨德拉病毒和尼帕病毒等致命病毒通过抑制宿主免疫系统，形成了有效的复制机制。在这里，我们将研究病毒如何执行这些免疫逃避功能，并测试能够以高度特异性的方式阻止这些作用的抗病毒药物。如果这个想法能够被证明，它将为开发新的抗病毒药物提供巨大的希望，同时最大限度地减少对细胞的毒性作用。