Understanding the regulation of the location of chromosomes within the nucleus

了解细胞核内染色体位置的调节

• 批准号: nhmrc : GNT1035229
• 负责人: Dr Carolyn de Graaf
• 金额: $ 33.36万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-regulation-location-chromosomes-nucleus/1344335
• 关键词: Understanding; regulation; location; chromosomes; within

The nucleus of each human cell, despite being under 10µM in diameter, contains 46 chromosomes, each consisting of several centimeters of DNA. The organisation of chromosomes within the nucleus helps regulate which genes are switched on and off. Genes attached to the nuclear lamina, which lines the nuclear membrane, tend to be switched off. Mutations in the nuclear lamina cause several diseases, including progeria, resulting premature aging. I am interested in understanding why only certain regions of the genome attach to the nuclear lamina.

每个人类细胞的细胞核，尽管直径小于10微米，但含有46条染色体，每条染色体由几厘米长的DNA组成。细胞核内染色体的组织有助于调节哪些基因被打开和关闭。附着在核膜上的核纤层上的基因往往会被关闭。核纤层中的突变导致几种疾病，包括早衰症，导致过早衰老。我对理解为什么只有基因组的某些区域附着在核纤层上很感兴趣。