Understanding the role of the putative phospholipid translocase ATP11c in B cell development

了解假定的磷脂转位酶 ATP11c 在 B 细胞发育中的作用

• 批准号: nhmrc : 1061288
• 负责人: A/Pr Richard Callaghan
• 金额: $ 30.35万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-putative-cell-development/454878
• 关键词: Understanding; role; putative; phospholipid; translocase

The immune system protects humans against recurrent infections with a wide range of pathogens. Formation of antibodies is a crucial element of the immune response. Defects in the production of antibodies can lead to recurrent and often life-threatening infections. This project seeks to understand a genetic defect in mice resulting in an almost complete absence of antibody producing cells, thereby causing a disease that is similar to some forms of human immunodeficiency.

免疫系统可以保护人类免受多种病原体的反复感染。抗体的形成是免疫反应的关键要素。抗体产生的缺陷可能导致反复感染，并且常常危及生命。该项目旨在了解小鼠的遗传缺陷，该缺陷导致小鼠几乎完全没有产生抗体的细胞，从而导致类似于某些形式的人类免疫缺陷的疾病。