Understanding the role of three-dimensional genome organisation in B cell lineage commitment and leukaemia.

了解三维基因组组织在 B 细胞谱系定型和白血病中的作用。

• 批准号: nhmrc : 1124081
• 负责人: Dr Timothy Johanson
• 金额: $ 21.75万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-three-commitment-leukaemia/947272
• 关键词: Understanding; role; three; dimensional; genome

Every one of your nuclei contain 2 metres of DNA. This DNA is 300,000 times longer than the nucleus itself. In order to fit into this space, while maintaining access to crucial genes, the DNA forms a fantastically ordered three-dimensional structure. This intricate organisation is crucial to health, with even minute changes driving diseases, such as cancer and heart disease. We propose using new technology to understand how this organisation changes during immune cell development and leukaemia.

你的每个细胞核都含有2米长的DNA。这个DNA比细胞核本身长30万倍。为了适应这个空间，同时保持对关键基因的访问，DNA形成了一个非常有序的三维结构。这种复杂的组织对健康至关重要，即使是微小的变化也会导致癌症和心脏病等疾病。我们建议使用新技术来了解该组织在免疫细胞发育和白血病期间如何变化。