Understanding the role of circular RNAs in neuronal biology using RNA-targeting CRISPR/Cas9

使用 RNA 靶向 CRISPR/Cas9 了解环状 RNA 在神经元生物学中的作用

• 批准号: nhmrc : 1106112
• 负责人: Dr Mitchell O'Connell
• 金额: $ 26.55万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-circular-targeting-crisprcas9/662885
• 关键词: Understanding; role; circular; RNAs; neuronal

The regulation of gene expression through a process known as RNA splicing has been shown to be at the heart of a number of processes required for brain development, memory and learning, and is often dysregulated in a number of neurological diseases. Circular RNAs (circRNAs) have been recently shown to be a relatively abundant class of spliced RNA that are specifically enriched in brain tissue. In this project, I aim to understand the roles of circRNAs in neuronal development.

通过称为RNA剪接的过程调节基因表达已被证明是大脑发育，记忆和学习所需的许多过程的核心，并且通常在许多神经系统疾病中失调。环状RNA（circRNA）最近已被证明是一类相对丰富的剪接RNA，其特异性地富集在脑组织中。在这个项目中，我的目标是了解circRNA在神经元发育中的作用。