Understanding the role of circular RNAs in neuronal biology using RNA-targeting CRISPR/Cas9

通过一种名为RNA剪接的过程来调控基因表达，已被证明是大脑发育、记忆和学习所需的一系列过程的核心，而且在许多神经疾病中往往处于失调状态。环状RNA(CircRNAs)最近被证明是一类相对丰富的剪接RNA，特异性地富含在脑组织中。在这个项目中，我的目标是了解CircRNAs在神经元发育中的作用。

The regulation of gene expression through a process known as RNA splicing has been shown to be at the heart of a number of processes required for brain development, memory and learning, and is often dysregulated in a number of neurological diseases. Circular RNAs (circRNAs) have been recently shown to be a relatively abundant class of spliced RNA that are specifically enriched in brain tissue. In this project, I aim to understand the roles of circRNAs in neuronal development.