Unravelling Plasmodium vivax transmission to Anopheles mosquitoes: Role of naturally acquired transmission blocking immunity and efficacy of novel vaccine and drug candidates

解开间日疟原虫向按蚊的传播：自然获得性传播阻断免疫的作用以及新型疫苗和候选药物的功效

• 批准号: nhmrc : GNT1141441
• 负责人: Dr Stephan Karl
• 金额: $ 43.1万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-plasmodium-vivax-drug-candidates/1348377
• 关键词: Unravelling; Plasmodium; vivax; transmission; Anopheles

This project is aimed at better understanding transmission of P. vivax, the world’s most widely spread malaria parasite. Using a newly established experimental platform that enables us to feed P. vivax infected blood to Anopheles farauti mosquitoes, we can start researching factors in human blood that determine P. vivax infection success, test new vaccine and drug candidates for their ability to block transmission and thus significantly advance science surrounding this neglected parasite.

该项目旨在更好地了解间日疟原虫的传播，间日疟原虫是世界上传播最广泛的疟疾寄生虫。使用一个新建立的实验平台，使我们能够将间日疟原虫感染的血液喂给法罗按蚊，我们可以开始研究人类血液中决定间日疟原虫感染成功的因素，测试新的疫苗和候选药物阻止传播的能力，从而显著推进围绕这种被忽视的寄生虫的科学研究。