Upregulation of dyskerin augments telomerase enzyme activity in haematopoietic cells
Upregulation of dyskerin augments telomerase enzyme activity in haematopoietic cells
批准号:
nhmrc : 1007911
负责人:
Dr Karen Mackenzie
金额:
$24.81万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The replication of cancer cells is unrestricted - they are immortal. Activation of the enzyme telomerase promotes immortalisation in 90% of human cancers. Conversely, telomerase deficiency causes life threatening blood disorders. We will investigate how one of the protein components of telomerase regulates enzyme activity in normal and leukaemic blood cells. The results will be valuable in the pursuit of new approaches to halting cancer cell replication and treating severe blood disorders.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Therapeutic implications of a molecular link between survivin and telomerase reverse transcriptase
-
批准号:nhmrc : 568704
-
项目类别:NHMRC Project Grants
-
资助金额:$36.54万
-
财政年份:2009
-
负责人:Dr Karen Mackenzie
-
依托单位:
Molecular regulation of replicative lifespan; implications in carcinogenesis and haematopoiesis
-
批准号:nhmrc : 510378
-
项目类别:Career Development Fellowships
-
资助金额:$28.06万
-
财政年份:2008
-
负责人:Dr Karen Mackenzie
-
依托单位:
国内基金
海外基金
靶向Dyskerin-NOP10相互作用的特异性小分子:优化设计合成及抑制端粒酶活化
-
批准号:21977001
-
项目类别:面上项目
-
资助金额:66.0万元
-
批准年份:2019
-
负责人:刘新华
-
依托单位: