Using exercise to target the epigenome of the ageing skeletal muscle

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Physical activity promotes healthy ageing, but the underlying mechanisms are still unknown. In this project, I hypothesise that physical activity slows down the ageing process via epigenetic mechanisms and some individuals have a genetic background that predisposes them to reap more benefit from physical activity. I will use data collected from the Gene SMART study to test those hypotheses, with the help of leaders in the fields of genetics, epigenetics, exercise and ageing.