Using immunological principles to inform malaria vaccine design

利用免疫学原理指导疟疾疫苗设计

• 批准号: nhmrc : 2003035
• 金额: $ 57.78万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-immunological-principles-vaccine-design/1780059
• 关键词: Using; immunological; principles; inform; malaria

Malaria kills ~420,000 people each year worldwide. While a vaccine does exist, efficacy is poor and protection wanes rapidly. We have made breakthroughs in understanding the immune response to malaria that allow us to design a new generation of malaria vaccines. Based on this we aim to generate a vaccine that induces sustained levels of high-quality antibodies targeting multiple targets on the parasite and so can provide sustained long-term protection.

疟疾每年在全球夺去约 42 万人的生命。虽然疫苗确实存在，但功效很差并且保护作用迅速减弱。我们在了解疟疾免疫反应方面取得了突破，使我们能够设计新一代疟疾疫苗。在此基础上，我们的目标是生产一种疫苗，能够诱导针对寄生虫多个目标的持续水平的高质量抗体，从而提供持续的长期保护。