Using a fragment-based approach to develop inhibitors of coenzyme A biosynthesis in Mycobacterium tuberculosis, the bacterium that causes tuberculosis

使用基于片段的方法开发结核分枝杆菌（结核病细菌）中辅酶 A 生物合成的抑制剂

• 批准号: nhmrc : 1016357
• 负责人: Dr Christina Spry
• 金额: $ 22.28万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-fragment-based-causes-tuberculosis/109769
• 关键词: Using; fragment; based; approach; develop

The metabolism of vitamin B5 by pathogenic microorganisms has been recognised as an attractive target for developing drugs to combat various infectious diseases. The aim of the proposed work is to develop inhibitors of vitamin B5 metabolism in the bacterium that causes tuberculosis, using a powerful, multidisciplinary approach known as “fragment-based drug discovery”. This work is likely to yield potent inhibitors of the target bacterium, which could ultimately be used to treat tuberculosis.

病原微生物对维生素B5的代谢已被认为是开发对抗各种感染性疾病的药物的有吸引力的目标。拟议工作的目的是开发导致结核病的细菌中维生素B5代谢的抑制剂，使用称为“基于片段的药物发现”的强大的多学科方法。这项工作可能会产生目标细菌的有效抑制剂，最终可用于治疗结核病。