Using a novel assay that detects antigen specific CD4+ and regulatory T cells to further understand reconstitution of antigen specific immune response post anti-retroviral therapy in subjects with HIV and in the diagnosis of latent TB

使用检测抗原特异性 CD4 和调节性 T 细胞的新型检测方法，进一步了解 HIV 患者抗逆转录病毒治疗后抗原特异性免疫反应的重建以及潜伏性结核病的诊断

• 批准号: nhmrc : 1017383
• 负责人: Dr Denise Hsu
• 金额: $ 6.85万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-novel-assay-latent-tb/109856
• 关键词: Using; novel; assay; detects; antigen

The process by which the immune system recovers after commencement of therapy for HIV is not well understood. We will use a new test to monitor the immune system's ability to recognise and react to different antigens inorder to understand the factors that affect immune recovery in patients on therapy for HIV. We will also evaluate the use of this new test in the diagnosis of latent TB. Improvement in detection will lead to treatment of latent TB thus reduction of cases of active TB.

艾滋病毒治疗开始后，免疫系统恢复的过程还不是很清楚。我们将使用一种新的测试来监测免疫系统识别不同抗原并对其做出反应的能力，以了解影响艾滋病毒治疗患者免疫恢复的因素。我们还将评估这一新检测方法在诊断潜伏性结核病方面的应用。检测的改进将导致治疗潜伏性结核病，从而减少活动性结核病病例。