Validating CaMKK2 as a Rational Treatment Target for Bipolar Disorder

双相情感障碍是一种致残的慢性精神疾病，严重损害受影响个人的日常生活能力。现有的双相情感障碍治疗方法不足，缺乏长期治疗所需的必要疗效和耐受性。该项目将验证这种酶，CAMKK2，作为双相情感障碍的合理治疗目标，这将指导开发更有效和更安全的药物，以改善患者的预后。

Bipolar disorder is a disabling, chronic mental illness that profoundly impairs the ability of affected individuals to function in daily life. Existing treatments for bipolar disorder are inadequate and lack the necessary efficacy and tolerability required for long-term therapy. This project will validate the enzyme, CaMKK2, as a rational treatment target for bipolar disorder, which will guide the development of more effective and safer drugs to improve patient outcomes.