Vascular changes are a key contributor to and novel drug target for interferon-alpha induced neurological disease

血管变化是干扰素α诱导的神经系统疾病的关键因素和新的药物靶点

• 批准号: nhmrc : 2001543
• 金额: $ 124.54万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vascular-changes-key-neurological-disease/1779801
• 关键词: Vascular; changes; key; contributor; novel

Type I interferons (IFN-Is) contribute to wide range of neurological diseases including ageing and neurodegeneration. At its extreme IFN-I-mediated neurodegeneration is known as 'interferonopathy'. The mechanisms of how IFN-Is drive disease are unclear, making causal treatment difficult. We have recently uncovered ground-breaking evidence that abnormal blood vessels are a key contributor to the disease. Here, we will investigate novel treatment targets for patients with interferonopathies.

I 型干扰素 (IFN-Is) 会导致多种神经系统疾病，包括衰老和神经退行性疾病。 IFN-I 介导的神经变性在极端情况下被称为“干扰素病”。 IFN-Is 驱动疾病的机制尚不清楚，这使得病因治疗变得困难。我们最近发现了突破性的证据，表明异常血管是导致这种疾病的关键因素。在这里，我们将研究干扰素病患者的新治疗靶点。