Venoms to drugs: characterizing the molecular interactions between venom peptides and ion channels with a view to rational drug design

毒液与药物：表征毒液肽和离子通道之间的分子相互作用，以实现合理的药物设计

• 批准号: nhmrc : 1071293
• 负责人: Dr Evelyne Deplazes
• 金额: $ 21.1万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/venoms-drugs-characterizing-drug-design/455462
• 关键词: Venoms; drugs; characterizing; molecular; interactions

The conventional approach to drug development is reaching a state of crisis as it is producing fewer new drugs at increasing cost. A promising alternative is to harness the rich and diverse chemistry of venom peptides. This project aims to understand the mechanism by which venom peptides achieve their pharmacological activity. This knowledge is essential for venom-based drug design for treating diseases ranging from nervous systems disorders, stroke, chronic pain and psychiatric illnesses.

传统的药物开发方法正在达到一种危机状态，因为它生产的新药越来越少，成本却越来越高。一个有希望的替代方法是利用毒液肽丰富多样的化学成分。本项目旨在了解毒液肽实现其药理活性的机制。这一知识对于设计基于毒液的药物来治疗神经系统疾病、中风、慢性疼痛和精神疾病等疾病至关重要。