Viral hijacking of the nucleolar DNA damage response machinery: novel mechanisms to regulate host cell biology

为了引起疾病，病毒进入宿主细胞并建立新的后代病毒粒子，这些病毒粒子传播并导致进一步的感染。对此至关重要的是，病毒通过对细胞结构进行重新编程，将宿主细胞转化为病毒工厂的能力。利用高致命性病原体，我们确定了一种新的策略，通过病毒模仿正常的细胞反应来改变细胞合成机制。通过阐明这些机制，这项工作应该确定新的潜在治疗靶点。

To cause disease, viruses enter host cells and build new progeny virions, that spread and cause further infections. Critical to this is the ability of viruses to transform host cells into virus factories by ‘reprograming’ the cellular machinery. Using highly lethal pathogens, we identified a new strategy by which viruses mimic normal cellular responses to change the cellular synthetic machinery. By elucidating these mechanisms, this work should identify new potential targets for therapies.