Viral hijacking of the nucleolar DNA damage response machinery: novel mechanisms to regulate host cell biology

病毒劫持核仁 DNA 损伤反应机制：调节宿主细胞生物学的新机制

• 批准号: nhmrc : GNT1160838
• 金额: $ 65.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-hijacking-nucleolar-cell-biology/1379147
• 关键词: Viral; hijacking; nucleolar; DNA; damage

To cause disease, viruses enter host cells and build new progeny virions, that spread and cause further infections. Critical to this is the ability of viruses to transform host cells into virus factories by ‘reprograming’ the cellular machinery. Using highly lethal pathogens, we identified a new strategy by which viruses mimic normal cellular responses to change the cellular synthetic machinery. By elucidating these mechanisms, this work should identify new potential targets for therapies.

为了引起疾病，病毒进入宿主细胞并建立新的子代病毒体，这些病毒体传播并引起进一步的感染。这其中的关键是病毒通过“重编程”细胞机制将宿主细胞转化为病毒工厂的能力。使用高致死性病原体，我们确定了一种新的策略，通过这种策略，病毒模仿正常的细胞反应来改变细胞合成机制。通过阐明这些机制，这项工作应该确定新的潜在治疗靶点。