Viral hijacking of the nucleolar DNA damage response machinery: novel mechanisms to regulate host cell biology

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To cause disease, viruses enter host cells and build new progeny virions, that spread and cause further infections. Critical to this is the ability of viruses to transform host cells into virus factories by ‘reprograming’ the cellular machinery. Using highly lethal pathogens, we identified a new strategy by which viruses mimic normal cellular responses to change the cellular synthetic machinery. By elucidating these mechanisms, this work should identify new potential targets for therapies.