How viral infection impairs anti-inflammatory drug effectiveness

病毒感染如何损害抗炎药物的有效性

• 批准号: nhmrc : GNT1072108
• 负责人: Dr Yuxiu Xia
• 金额: $ 20.31万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-infection-impairs-drug-effectiveness/1345030
• 关键词: How; viral; infection; impairs; anti

Anti-inflammatory types of steroid drugs are commonly used in chronic lung disease including asthma and chronic obstructive pulmonary disease. However, a significant number of sufferers show resistance to the steroid therapy. Our study is developing an understanding of how inflammation limits the anti-inflammatory effects of steroids and we are identifying novel therapeutic targets to improve the effectiveness of treatment of chronic disease.

抗炎类型的类固醇药物通常用于慢性肺病，包括哮喘和慢性阻塞性肺病。然而，相当数量的患者对类固醇治疗表现出抗性。我们的研究正在了解炎症如何限制类固醇的抗炎作用，我们正在确定新的治疗靶点，以提高慢性疾病的治疗效果。