Apoptosis associated with the Equine arteritis virus, a model for nidoviruses

与马动脉炎病毒（巢病毒的模型）相关的细胞凋亡

• 批准号: 118705-2010
• 负责人: Archambault, Denis
• 金额: $ 2.29万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=451458
• 关键词: Apoptosis; associated; Equine; arteritis; virus

Apoptosis is considered the physiological form of cell death which occurs during embryonic development, tissue remodelling and tumor regression. Among stimuli that have been associated with cell apoptosis are infections with mammalian DNA and RNA viruses. Upon virus infection, the cell may react to viral aggression by undergoing early apoptosis to prevent production and/or dissemination of progeny viruses. To achieve successful replication, certain viruses have evolved mechanisms to suppress and induce apoptosis in early and late stages of infection, respectively, enlighten further the complexity of virus-host interactions. Our proposal will examine these interactions between viruses and the host apoptotic machinery that would contribute to the understanding of virus replication and pathogenesis. More particularly, we will identify viral determinants and the mechanisms associated to apoptosis. Identifying pro- and anti-apoptotic viral-derived proteins and their modes of action might also contribute to the development of therapies in humans to kill or preserve particular type of cells.

细胞凋亡被认为是胚胎发育、组织重塑和肿瘤消退过程中细胞死亡的一种生理形式。与细胞凋亡相关的刺激因素包括哺乳动物DNA和RNA病毒的感染。一旦病毒感染，细胞可能会对病毒的攻击做出反应，通过早期的细胞凋亡来防止后代病毒的产生和/或传播。为了实现成功的复制，某些病毒已经进化出机制，分别在感染的早期和晚期抑制和诱导细胞凋亡，进一步揭示了病毒与宿主相互作用的复杂性。我们的建议将研究病毒和宿主细胞凋亡机制之间的这些相互作用，这将有助于理解病毒复制和发病机制。更具体地说，我们将确定病毒决定因素和与细胞凋亡相关的机制。识别促和抗凋亡病毒衍生蛋白及其作用模式也可能有助于开发人类杀死或保存特定类型细胞的治疗方法。