Cortical modulation of nucleus accumbens cholinergic neurons

伏隔核胆碱能神经元的皮质调节

• 批准号: 184095-2009
• 负责人: Warren, Richard
• 金额: $ 1.82万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=452527
• 关键词: Cortical; modulation; nucleus; accumbens; cholinergic

A better understanding of the brain regions involved in mental disorders will eventually lead to the development of better medication. The objective of this research proposal is to better understand the function of the nucleus accumbens, a brain structure involved in schizophrenia and drug abuse. Our interest concerns a small population of nucleus accumbens neurons that uses acetylcholine as a neurotransmitter. We will study the properties of thes neurons as well as their interactions with other neuronal populations using eletrophysiological and pharmacological techniques.

更好地了解涉及精神障碍的大脑区域最终将导致更好的药物治疗的发展。 这项研究计划的目的是更好地了解神经核的功能，神经核是一种与精神分裂症和药物滥用有关的大脑结构。 我们感兴趣的是一小群使用乙酰胆碱作为神经递质的丘脑核神经元。 我们将利用电生理学和药理学技术研究这些神经元的特性以及它们与其他神经元群体的相互作用。