VULNERABILITY OF THE INTRAUTERINE GROWTH RESTRICTED HEART AND KIDNEY TO ELEVATIONS IN BLOOD GLUCOSE LEVELS IN ADULTHOOD

胎儿宫内生长受限的心脏和肾脏对成年期血糖水平升高的脆弱性

• 批准号: nhmrc : 519410
• 负责人: Dr Kyungjoon (Joon) Lim
• 金额: $ 3.89万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vulnerability-intrauterine-growth-levels-adulthood/115715
• 关键词: VULNERABILITY; INTRAUTERINE; GROWTH; RESTRICTED; HEART

It is proposed that the hearts and kidneys of subjects that were born small for gestational age are particularly vulnerable to the pathophysiological changes induced by hyperglycemia, even when blood glucose levels are only mildly elevated. In the present project, this concept will be investigated. The outcomes of this study will be particularly relevant to the Australian Aboriginal population, as they have a higher incidence than normal of low birth weight and impaired glucose metabolism.

有人提出，出生时小于胎龄儿的受试者的心脏和肾脏特别容易受到高血糖症诱导的病理生理变化的影响，即使血糖水平仅轻度升高。在本项目中，将研究这一概念。本研究的结果与澳大利亚原住民群体特别相关，因为他们的低出生体重和糖代谢受损的发生率高于正常人群。