Development of Liposaccharide Peptide Conjugates for Peptide Drug Delivery.

用于多肽药物传递的脂多糖肽偶联物的研究进展。我们的目标是采用由Alchemia专利的固相寡糖合成技术来开发方法，使糖，脂质和肽单元能够在单个固相树脂上组装。然后，该合成技术将用于生成两种模型肽（LHRH和TRH）的脂多糖偶联物库，以研究和优化广泛适用的肽药物传递系统，该系统可改善肽的口服吸收，代谢稳定性和生物利用度。

Development of Liposaccharide Peptide Conjugates for Peptide Drug Delivery. We aim to adapt the Solid Phase Oligosaccharide Synthesis technology patented by Alchemia to develop methodologies that will allow the assembly of sugar, lipid and peptide units on a single solid phase resin. This synthetic technology will then be used to generate a library of liposaccharide conjugates of two model peptides (LHRH and TRH) to investigate and optimise a broadly applicable peptide drug delivery system which improves peptides oral absorption, metabolic stability and bioavailability.