Neuroplasticity-associated immediate early gene expression in forebrain sensory systems of normal and congenitally blind animal models

正常和先天性失明动物模型前脑感觉系统中神经可塑性相关的早期基因表达

• 批准号: 53-2009
• 负责人: Miceli, Dom
• 金额: $ 1.89万
• 依托单位: Université du Québec à Trois-Rivières
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=473268
• 关键词: Neuroplasticity; associated; immediate; early; gene

A specific set of immediate-early genes (IEGs) are regulated by synaptic activity and play an important role in brain development giving rise to stable and functioning brain circuits. The IEG arc/arg3.1 has been shown to be involved in long-term changes and to directly modulate synaptic processes underlying memory and the encoding of novelty-related events. All stimuli involve a memory component in which each stimulus is compared to previously encoded stimuli for it to be considered novel or familiar.

一组特定的立即早期基因（IEGs）受突触活动的调节，在大脑发育中发挥重要作用，产生稳定和功能性的大脑回路。IEG arc/arg3.1已被证明参与长期变化，并直接调节记忆和新奇相关事件编码的突触过程。所有的刺激都涉及记忆成分，其中每个刺激都与先前编码的刺激进行比较，以将其视为新的或熟悉的。