Synthetic methodologies and natural prouduct synthesis

合成方法学和天然产物合成

• 批准号: 105963-2007
• 负责人: MaGee, David
• 金额: $ 1.82万
• 依托单位: University of New Brunswick
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=475394
• 关键词: Synthetic; methodologies; natural; prouduct; synthesis

The chemical synthesis of carbon based compounds has been a major field of scientific curiosity for over a century, and the subject is still far from being fully developed. As our knowledge of chemical sciences (both fact and theory) has grown so has the power of synthesis. The construction of organic compounds now includes the use of reactions and reagents involving more than sixty of the chemical elements, even though only a dozen or so elements are commonly contained in commercially or biologically significant molecules. Our group is interested in the development of new and/or simpler ways to make biologically exciting and structurally challenging natural products in optically pure form. Although nature is the usual supplier of these "new drugs", it is often times only in very small quantities, in one optical form (the particular arrangement of atoms in 3-dimensional space) and/or not in the most "potent" structure. It is then incumbent upon the synthetic organic chemist to not only make these new compounds in an optically pure form (as cheaply as possible), but also to make them as active as possible (allowing for small doses to be taken) and as specific as possible (little or no side affects). Consequently, we are continuing a program designed at developing methodology to synthesize 7 and 8 membered ring carbocyclic compounds in optically enriched form. Concurrent with this project we are looking at expanding our previous work on ketene chemistry. This will provide quick access to more highly functionalized systems that can be readily used for the synthesis of biologically important compounds, including anti-cancer compounds. The methodology will provide industry and academia new and more direct methods to synthesize these types of compounds, thus providing the potential for the development of new drugs for use in the treatment of diseases.

一个多世纪以来，碳基化合物的化学合成一直是科学好奇的主要领域，但该学科仍远未​​得到充分发展。 随着我们对化学科学知识（事实和理论）的增长，合成的力量也在不断增长。 有机化合物的构建现在包括使用涉及六十多种化学元素的反应和试剂，尽管商业或生物重要分子中通常只包含十几种元素。 我们的团队有兴趣开发新的和/或更简单的方法，以光学纯的形式制造具有生物学兴奋性和结构挑战性的天然产品。 尽管大自然是这些“新药”的通常供应者，但通常数量非常少，以一种光学形式（原子在 3 维空间中的特定排列）和/或不是最“有效”的结构。 然后，合成有机化学家有责任不仅以光学纯的形式（尽可能便宜）制造这些新化合物，而且还要使它们尽可能活跃（允许服用小剂量）和尽可能具体（很少或没有副作用）。 因此，我们正在继续一项旨在开发合成光学富集形式的 7 元环和 8 元环碳环化合物的方法的计划。在这个项目的同时，我们正在考虑扩展我们之前在乙烯酮化学方面的工作。 这将提供对功能更高的系统的快速访问，这些系统可轻松用于合成生物学上重要的化合物，包括抗癌化合物。该方法将为工业界和学术界提供新的、更直接的方法来合成这些类型的化合物，从而为开发用于治疗疾病的新药提供潜力。