Backbone Modified Cyclic Peptides: Scaffolds for Supramolecular Chemistry

主链修饰的环肽：超分子化学的支架

• 批准号: ARC : DP0208266
• 金额: $ 75.55万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/backbone-modified-cyclic-supramolecular-chemistry/64974
• 关键词: Backbone; Modified; Cyclic; Peptides; Scaffolds

Backbone Modified Cyclic Peptides: Scaffolds for Supramolecular Chemistry. The synthesis of compounds that mimic Nature's catalysts - enzymes - will provide us with a better understanding of how these intriguing molecules function and may lead to the development of new catalysts for industrial processes. Modified cyclic peptides could be used as platforms to arrange catalytic groups in a spatially well-defined manner to mimic enzymes. As cyclic peptides are often difficult to prepare, I aim to develop a powerful general method for their synthesis. This methodology will then be applied to the synthesis of cyclic peptide-based enzyme mimics.

骨架修饰的环肽：超分子化学的支架。模拟自然催化剂-酶-的化合物的合成将使我们更好地了解这些有趣的分子如何发挥作用，并可能导致工业过程中新催化剂的开发。修饰的环肽可以作为平台，以空间上明确的方式排列催化基团以模拟酶。由于环肽通常很难制备，我的目标是开发一个强大的通用方法来合成它们。然后将该方法应用于基于环肽的酶模拟物的合成。