Mechanistic studies on shikimate pathway enzymes

莽草酸途径酶的机理研究

• 批准号: 138038-2009
• 负责人: Turnbull, Joanne
• 金额: $ 2.33万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=475752
• 关键词: Mechanistic; studies; shikimate; pathway; enzymes

Enzymes can accelerate chemical reactions by more than a million-fold. We are interested in understanding how amino acid residues within enzymes bring about this rate acceleration. Some residues are involved in binding, others participate in the chemistry of the reaction, while other groups are involved in both. Enzymes can also be inhibited by the direct products or end products of the pathway to which they belong.

酶可以将化学反应加速一百万倍以上。 我们感兴趣的是了解酶中的氨基酸残基是如何导致这种速率加速的。一些残基参与结合，其他残基参与反应的化学过程，而其他基团则参与两者。酶也可以被它们所属途径的直接产物或终产物抑制。