Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
基本信息
- 批准号:138878-2007
- 负责人:
- 金额:$ 4.46万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2011
- 资助国家:加拿大
- 起止时间:2011-01-01 至 2012-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objectives of the research proposed in this application are to continue our identification of specific neuroanatomical and neurochemical systems that underlie appetitive and consummatory aspects of sexual behavior in female and male rats. A combination of neuropharmacological and molecular techniques will be used to examine the role of monoamines (dopamine and serotonin), small molecules (glutamate and GABA), and neuropeptides (opioids, melanocortins, oxytocin) within mesolimbic and hypothalamic brain regions in response to different types of sexual stimulation. These stimuli will include pheromonal cues and genitosensory stimulation. In vivo microdialysis will be used to characterize dopamine, glutamate, GABA (or different neuropeptides) in mesolimbic and hypothalamic regions during sexual interactions. The research will focus on the mechanisms that control sexual arousal, desire, reward, inhibition, and disinhibition, and will focus on solicitation and pacing behaviors in female rats, and sexual anticipation and chasing behaviors in male rats, in addition to traditional consummatory measures of lordosis and mounting behavior. The development and maintenance of appetitive sexual behaviors appear to require the activation of sexual reward systems following ejaculation in male rats or paced vaginocervical stimulation in female rats. Our previous work has indicated an interaction between the medial preoptic area and ventromedial nucleus of the hypothalamus, the ventral tegmental area of the midbrain, and several amygdala nuclei in generation of sexual reward expectancies. In addition to studies of appetitive sexual behavior, the neural systems that underlie sexual inhibition will begin to be elucidated by pairing sexually active rats with nonreceptive partners, by examining the mechanisms of sexual refractoriness or estrus termination, and by examining the effects of sexual nonreward during an animal's first sexual experiences. This work will provide new insights into the neural control of appetitive and consummatory sexual behaviors in rats, behaviors that can be viewed as models of human sexual arousal, desire, and copulatory performance.
本申请中提出的研究目标是继续我们对雌性和雄性大鼠性行为的食欲和性行为完成方面的特定神经解剖学和神经化学系统的鉴定。 神经药理学和分子技术的结合将被用来检查的作用,单胺类(多巴胺和血清素),小分子(谷氨酸和GABA),和神经肽(阿片类药物,黑皮质素,催产素)在中脑边缘和下丘脑的大脑区域内的反应不同类型的性刺激。 这些刺激将包括信息素线索和生殖器感觉刺激。在体内微透析将被用来表征多巴胺,谷氨酸,GABA(或不同的神经肽)在中脑边缘和下丘脑区域在性的相互作用。 该研究将重点关注控制性唤起、欲望、奖励、抑制和去抑制的机制,除了传统的完善措施外,还将重点关注雌性大鼠的恳求和起搏行为,以及雄性大鼠的性预期和追逐行为。脊柱前凸和安装行为的测量。在雄性大鼠射精或雌性大鼠起搏阴道宫颈刺激后,食欲性行为的发展和维持似乎需要性奖赏系统的激活。 我们以前的工作表明,下丘脑的内侧视前区和腹内侧核,中脑的腹侧被盖区和几个杏仁核之间的相互作用,在性奖励预期的产生。 除了对食欲性行为的研究之外,性抑制背后的神经系统也将开始通过将性活跃的大鼠与非接受性伴侣配对,通过检查性不应或发情终止的机制,以及通过检查动物首次性体验期间性非奖赏的影响来阐明。 这项工作将为大鼠食欲和性行为的神经控制提供新的见解,这些行为可以被视为人类性唤起,欲望和交配表现的模型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Pfaus, James其他文献
Bremelanotide: An overview of preclinical CNS effects on female sexual function
- DOI:
10.1111/j.1743-6109.2007.00610.x - 发表时间:
2007-11-01 - 期刊:
- 影响因子:3.5
- 作者:
Pfaus, James;Giuliano, Francois;Gelez, Helene - 通讯作者:
Gelez, Helene
Viewing Sexual Stimuli Associated with Greater Sexual Responsiveness, Not Erectile Dysfunction.
- DOI:
10.1002/sm2.58 - 发表时间:
2015-06 - 期刊:
- 影响因子:2.6
- 作者:
Prause, Nicole;Pfaus, James - 通讯作者:
Pfaus, James
Experimental Models for the Study of Female and Male Sexual Function
- DOI:
10.1111/j.1743-6109.2010.01960.x - 发表时间:
2010-09-01 - 期刊:
- 影响因子:3.5
- 作者:
Giuliano, Francois;Pfaus, James;Wallen, Kim - 通讯作者:
Wallen, Kim
Pfaus, James的其他文献
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{{ truncateString('Pfaus, James', 18)}}的其他基金
Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
- 批准号:
RGPIN-2018-05439 - 财政年份:2018
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2017
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2016
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2015
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2014
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2013
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2012
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2007 - 财政年份:2010
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2007 - 财政年份:2009
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
- 批准号:
349702-2007 - 财政年份:2009
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
相似海外基金
Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
- 批准号:
RGPIN-2018-05439 - 财政年份:2018
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2017
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2016
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2015
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2014
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2013
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and Neurochemistry of Sexual Behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2012 - 财政年份:2012
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2007 - 财政年份:2010
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
- 批准号:
138878-2007 - 财政年份:2009
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Individual
Neuroanatomy and neurochemistry of sexual behavior
性行为的神经解剖学和神经化学
- 批准号:
349702-2007 - 财政年份:2009
- 资助金额:
$ 4.46万 - 项目类别:
Discovery Grants Program - Accelerator Supplements