Cell envelope modulation in oral streptococci

口腔链球菌的细胞包膜调节

• 批准号: 183712-2011
• 负责人: Lee, Song
• 金额: $ 2.19万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=476400
• 关键词: Cell; envelope; modulation; oral; streptococci

Bacteria use components on their cell surface to interact with the environment and the host cells. We now recognize that bacteria can modulate or change the relative amount of these components on their cell surface and this ability of cell surface modulation plays an important role for the bacteria to be a successful pathogen or survival under a changing environment. Our research is to study how bacteria change the composition of their cell surface using the oral bacterium Streptococcus gordonii as a model. S. gordonii is a good model bacterium to study cell surface modulation because it lives in an environment that changes frequently due to eating and drinking. In addition, there are two types of surfaces, tooth (hard tissue) and mucosa (soft tissue), in the mouth for the bacterium to colonize. To deal with the changing environment and the two different types of colonizing surfaces, we believe S. gordonii needs to modulate the cell surface components to be successful. We will use molecular and biochemical techniques to understand the mechanism of cell surface modulation. The significance of the research is that the results will provide fundamental understandings of how the cell surface is modified in S. gordonii and the findings will likely be true for other bacteria. Therefore, the research results will play a big role in helping to design new methods to prevent infectious diseases.

细菌利用其细胞表面的成分与环境和宿主细胞相互作用。我们现在认识到，细菌可以调节或改变这些组分在其细胞表面上的相对量，并且这种细胞表面调节的能力对于细菌成为成功的病原体或在变化的环境下生存起着重要作用。 我们的研究是以口腔细菌戈登链球菌为模型，研究细菌如何改变其细胞表面的组成。 S.戈登氏菌是研究细胞表面调节的良好模式细菌，因为它生活在因饮食而频繁变化的环境中。 此外，口腔中有两种类型的表面，牙齿（硬组织）和粘膜（软组织）供细菌定植。 为了应对不断变化的环境和两种不同类型的殖民表面，我们相信S。gordonii需要调节细胞表面成分才能成功。 我们将使用分子和生物化学技术来了解细胞表面调节的机制。 本研究的意义在于为深入了解S. gordonii的研究结果很可能也适用于其他细菌。 因此，研究结果将在帮助设计预防传染病的新方法方面发挥重要作用。