Second messenger-activated calcium channels in liver cells

第二信使激活的肝细胞钙通道。该项目涉及第二信使激活钙通道，这是所有动物细胞功能所必需的信使激活钙通道家族的一部分。目的是阐明一种新的“大电导”钙通道（使用maitotoxin作为人工激活剂），肌醇1，4，5-三磷酸激活的钙通道，和瞬时受体电位-1（TRP-1）蛋白在肝细胞中形成的钙通道的特性。将研究通道的电生理特性、激活机制和细胞内运输。预期该结果将为第二信使激活钙通道的生理功能提供基础信息。这将有利于了解动物的肝功能、肝毒性、动物生产和畜牧业药品的开发。

Second messenger-activated calcium channels in liver cells. This project concerns second messenger-activated calcium channels, part of the family of hormone-activated calcium channels which are essential to the functions of all animal cells. The aims are to elucidate the properties of a novel "large conductance" Ca2+ channel (using maitotoxin as an artificial activator), an inositol 1,4,5-trisphosphate-activated calcium channel, and the calcium channel formed by the transient receptor potential-1 (TRP-1) protein in hepatocytes. The electrophysiological properties, mechanisms of activation and intracellular trafficking of the channels will be investigated. It is anticipated the results will provide basic information on the physiological functions of second messenger-activated calcium channels. This will benefit the understanding of liver function, hepatotoxicity in animals, animal production and the development of pharmaceuticals in animal husbandary.