Hsp90: chaperoning signal transduction in plants

Hsp 90是一种高度保守的分子伴侣，在信号转导、蛋白质降解和运输、染色质重塑和表观遗传调控等方面发挥着重要作用。Hsp 90的重要性表现在：1）通过调节各种信号转导途径在调节生长中不可或缺的作用; 2）作为形态进化的电容器的潜力;以及3）由于其与致癌蛋白的相互作用而作为癌症化疗靶点的位置。目前的项目重点是详细了解植物中Hsp 90的功能和作用方式。Hsp 90在植物中特别令人感兴趣，因为植物在其环境中经受突然的变化，Hsp 90蛋白家族是植物中最大的，并且植物含有额外的隔室，质体。对植物Hsp 90系统的深入了解将有助于我们理解蛋白质在植物细胞中是如何折叠、稳定、激活和运输的。

The highly conserved molecular chaperone Hsp90 plays key roles in signal transduction, protein degradation and trafficking, chromatin remodelling and epigenetic regulation. The significance of Hsp90 is indicated by its 1) indispensable role in regulating growth through modulations of various signal transduction pathways; 2) potential as a capacitor for morphological evolution; and 3) position as a cancer chemotherapeutic target due to its interactions with oncogenic proteins. The current project is focused on obtaining a detailed understanding of the functions and mode of action of Hsp90 in plants. Hsp90 is of particular interest in plants because plants are subjected to sudden changes in their environment, the Hsp90 protein family is the largest in plants, and plants contain an additional compartment, the plastid. A good knowledge of the plant Hsp90 system will facilitate our understanding of how proteins are folded, stabilised, activated and trafficked in plant cells.