Structural studies of plant disease resistance proteins

植物抗病蛋白的结构研究

• 批准号: ARC : DP0208353
• 负责人: Bostjan Kobe
• 金额: $ 31.8万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-studies-plant-resistance-proteins/69022
• 关键词: Structural; studies; plant; disease; resistance

Structural studies of plant disease resistance proteins. Plant cells have evolved a gene-for-gene disease resistance mechanism, involving an interaction of a plant-derived receptor with a specific pathogen-derived molecule. Currently, plant breeders are restricted to the resistance genes available in particular crop species or sexually compatible relatives. In the last few years, several plant disease resistance genes have been identified, providing a foundation for studying the molecular basis of the resistance process. We propose to obtain three-dimensional structural information on representative R proteins and their ligand complexes. This will form the basis for modifying existing resistance genes to confer resistance to new diseases, resulting in large economic benefits.

植物抗病蛋白的结构研究。植物细胞已经进化出一种基因对基因的抗病机制，涉及植物源性受体与特定病原体源性分子的相互作用。目前，植物育种者仅限于特定作物物种或性相容亲缘植物中可用的抗性基因。在过去的几年里，一些植物抗病基因已经被鉴定出来，为研究抗性过程的分子基础提供了基础。我们建议获得代表性 R 蛋白及其配体复合物的三维结构信息。这将为修改现有抗性基因以赋予对新疾病的抗性奠定基础，从而产生巨大的经济效益。