The Chemistry and Biochemistry of Chromium: Cancer and Nutrition

铬的化学和生物化学：癌症和营养。在所有人类致癌物中，铬(VI)的职业性接触水平最高，作为一种环境致癌物越来越受到关注，正如电影Erin Brockovitch所强调的那样。同样，尽管人们越来越担心铬(III)的致癌风险，但人类和动物的营养补充剂消费量正在迅速上升。然而，铬的生物化学非常复杂，人们对它的了解仍然很少。该项目旨在提供有关铬生物化学的新见解，对评估职业性和环境暴露的风险因素以及生产更安全的铬膳食补充剂具有重要意义。

The Chemistry and Biochemistry of Chromium: Cancer and Nutrition. Of all of the human carcinogens, chromium(VI) has the highest level of occupational exposure, and is of increasing concern as an environmental carcinogen, as highlighted by the film Erin Brockovitch. Similarly, chromium(III) nutritional supplement consumption by humans and animals is rising rapidly, despite mounting concerns about their cancer risks. However, the complexity of Cr biochemistry is such that it is still poorly understood. This project aims at providing new insights into Cr biochemistry that are of relevance in evaluating risk factors for occupational and environmental exposure and for producing safer Cr dietary supplements.