Multimodal sensory modulation and human motor control

多模态感觉调制和人体运动控制

• 批准号: 250364-2007
• 负责人: Staines, Richard
• 金额: $ 2.22万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=479593
• 关键词: Multimodal; sensory; modulation; human; motor

In order to interact in our environment during everyday activities, the central nervous system (CNS) must identify and extract relevant sensory information from a vast array of concurrent inputs from multiple sensory modalities. Such processing is essential for accurately controlling movements, learning novel motor skills and successfully relearning movement patterns following brain injury. Sensory inputs initially arrive and are processed at very distinct, modality specific areas of the cortex before being integrated in sensory association cortices. Previous research has provided detailed characterization and mechanistic information regarding how sensory inputs within a specific modality are represented during movement at a relatively early cortical level. For example, our ongoing research suggests that selection of somatosensory information begins to occur at the very earliest stage of cortical processing, the primary somatosensory cortex, during sensory-guided movement and perceptual discrimination. Highly selective mechanisms appear to be involved, including inhibition of ascending cortical paths carrying task-irrelevant information and facilitation of those carrying task-relevant information. The specific regions that control this selection are unclear, however interactions between the prefrontal cortex, thalamus, multimodal sensory regions and primary unimodal sensory cortices appear to play an important role. However, much less is known about how these mechanisms of control are altered when the central nervous system is presented with multiple sources of sensory inputs, as is usually the case during natural movement. Our current work suggests that the cortical representations of competitive visual and tactile input change substantially depending on the task-relevance of the stimuli and on the spatial and temporal relationship between visual and somatosensory information. As such the proposed research program will focus on developing fundamental understanding of the interactions and integration of sensory inputs from multiple modalities at a cortical level and the role this plays in the acquisition and control of normal limb movement.

为了在日常活动中与我们的环境相互作用，中枢神经系统（CNS）必须从来自多种感觉模态的大量并发输入中识别和提取相关的感觉信息。 这种处理对于准确控制运动、学习新的运动技能和成功地重新学习脑损伤后的运动模式至关重要。 感觉输入最初到达并在皮层的非常不同的、模态特定的区域进行处理，然后被整合到感觉联合皮层。以前的研究提供了详细的表征和机制信息，关于如何在一个特定的模态内的感觉输入表示在运动过程中在一个相对较早的皮层水平。 例如，我们正在进行的研究表明，在感觉引导运动和知觉辨别期间，对躯体感觉信息的选择开始发生在皮层处理的最早阶段，即初级躯体感觉皮层。 高度选择性的机制似乎参与，包括抑制上行皮层路径携带任务无关的信息和促进那些携带任务相关的信息。 控制这种选择的具体区域尚不清楚，但前额叶皮层，丘脑，多模态感觉区域和初级单峰感觉皮层之间的相互作用似乎发挥了重要作用。 然而，当中枢神经系统受到多种来源的感觉输入时，这些控制机制是如何改变的，就像自然运动中通常的情况一样，我们所知甚少。 我们目前的工作表明，竞争性视觉和触觉输入的皮质表征会根据刺激的任务相关性以及视觉和体感信息之间的空间和时间关系发生很大变化。 因此，拟议的研究计划将侧重于发展的相互作用和整合的感觉输入从多个模态在皮层水平的作用，这在正常的肢体运动的获取和控制的基本理解。