Glucocorticoid repression, Cushing disease and pituitary tumorigenesis

糖皮质激素抑制、库欣病和垂体肿瘤发生

• 批准号: 177932
• 负责人: Drouin Jacques
• 金额: $ 7.29万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2009-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=177932&lang=en
• 关键词: Cushing Disease; Glucocorticoids; Pituitary Tumours; Pomc; Repression; Transcription

Cushing disease is caused by small pituitary tumors that lead to excessive production of adrenal glucocorticoids. The excessive levels of these steroids lead to severe metabolic imbalance and may result in diabetes, hypertension and/or osteoporosis. The

库欣病是由垂体小肿瘤引起的，导致肾上腺糖皮质激素过量产生。这些类固醇水平过高会导致严重的代谢失衡，并可能导致糖尿病、高血压和/或骨质疏松症。的