Improved characterization of human somatosensory cortex using simultaneous vibro-tactile stimulation of multiple digits

使用多个手指同时振动触觉刺激改进人类体感皮层的表征

• 批准号: 341562-2007
• 负责人: Ross, Bernhard
• 金额: $ 1.89万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482162
• 关键词: Improved; characterization; human; somatosensory; cortex

Tactile sensation is encoded in the primary somatosensory cortex in topographical maps accordingly to the body surface. This topographical representation can be modified as the result of training and experience. This brain plasticity results from newly expressed or strengthened synaptic connections. The effect can be measured in humans noninvasively using magnetoencephalography (MEG) as increased activation or larger activated area on the cortical surface. Brain plasticity is an important factor for successful recovery from a stroke. We shall develop a new method for objectively monitoring of plastic reorganization in somatosensory cortex by measuring the size of the somatotopic hand area as indicated by the distance between finger representation. The finger representation in human somatosensory cortex can be localized with the MEG. The distance between fingers can be obtained from multiple MEG recordings with stimulating one finger after the other. However, head movements between recordings cause too large errors. With our new procedure we will stimulate multiple fingers at the same time with vibrations of different rate. We shall record brain activity at the frequencies of the vibration stimuli and can separate the responses from each finger. Those responses will be localized. The distance between finger representation can be measured with high precision because all recordings were done at the same time and were affected by head movements equally. We shall investigate the possible interactions between finger localizations and effects of attention in order to optimize the procedure. In summary we shall develop a highly precise method for measuring distances between body part representations in the cortex. Changes over time in the obtained distance measure indicate plastic reorganisation e.g. as the effect of therapeutic intervention.

触觉在初级体感皮层中以地形图的形式编码，与体表相对应。这种地形表示可以根据训练和经验进行修改。这种大脑可塑性来自于新表达或加强的突触连接。这种效应可以在人类中无创地使用脑磁图（MEG）来测量，因为大脑皮层表面的激活增加或激活面积增大。大脑的可塑性是中风成功康复的重要因素。我们将开发一种新的方法来客观地监测体感皮层的可塑性重组，通过测量手指表征之间的距离来指示体感手区域的大小。人体体感皮层的手指表征可以用脑磁图定位。手指之间的距离可以从多个MEG记录中获得，刺激一个手指接着另一个手指。然而，在录音之间的头部运动造成了太大的误差。通过我们的新方法，我们将同时用不同频率的振动刺激多个手指。我们将记录振动刺激频率下的大脑活动，并将每个手指的反应分开。这些反应将是局部的。由于所有记录都是在同一时间完成的，并且受到头部运动的相同影响，因此可以高精度地测量手指表示之间的距离。我们将研究手指定位和注意力效应之间可能的相互作用，以优化手术过程。总之，我们将开发一种高度精确的方法来测量大脑皮层中身体部位表征之间的距离。所获得的距离测量值随时间的变化表明可塑性重组，例如作为治疗干预的效果。