Assessing the role of hemodynamics in embryonic development

评估血流动力学在胚胎发育中的作用

• 批准号: 342134-2007
• 负责人: Jones, Elizabeth
• 金额: $ 1.93万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482436
• 关键词: Assessing; role; hemodynamics; embryonic; development

The cardiovascular system is the first functional organ in the embryo, and proper functioning of the early cardiovascular system is essential for embryonic health and survival. The blood vessels of the embryo are initially established by a process called vasculogenesis which occurs in the absence of blood flow. These early vessels are then remodeled through a secondary process that is known to be dependent on the presence of blood flow. In recent years, there has been a debate regarding which aspects of early vascular formation are genetically predetermined, and which are governed by external stimuli, such as mechanical and biochemical signaling. Though the initial vascular network is patterned without physiological feedback, once flow has begun, a separate set of physical and metabolic signals arise. Blood pressure, blood flow, and related physical forces such as circumferential wall stress and wall shear stress as well as metabolic information such as nutrient and oxygen requirements all can provide feedback to genetically encoded signaling mechanisms. The point at which the switch from genetic mechanisms to physiological feedback mechanisms occurs remains largely unexplored.

心血管系统是胚胎的第一个功能器官，早期心血管系统的正常功能对胚胎的健康和存活至关重要。胚胎的血管最初是通过称为血管发生的过程建立的，该过程在没有血流的情况下发生。 这些早期血管然后通过已知依赖于血流存在的次级过程重塑。近年来，关于早期血管形成的哪些方面是遗传预定的，哪些是由外部刺激（如机械和生化信号）控制的，一直存在争议。 虽然最初的血管网络是在没有生理反馈的情况下形成的，但一旦流动开始，就会出现一组单独的物理和代谢信号。 血压、血流和相关的物理力（如周向壁应力和壁剪切应力）以及代谢信息（如营养和氧气需求）都可以为遗传编码的信号传导机制提供反馈。从遗传机制到生理反馈机制的转换点在很大程度上尚未探索。