Investigation of the roles of schizophrenia susceptibility genes DISC1 and DTNBP1 in cognition, learning, memory, and rodent models of psychiatric disease

精神分裂症易感基因DISC1和DTNBP1在精神疾病认知、学习、记忆和啮齿动物模型中的作用研究

• 批准号: 184611
• 负责人: Feldcamp Laura A
• 金额: $ 7.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-10-01 至 2011-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=184611&lang=en
• 关键词: Disc1; Dysbindin1; Immunohistochemistry; In-Situ Hybridization; Learning And Memory; Lentiviral-Mediated Upregulation Of Mrna/Protein; Prepulse Inhibition; Real-Time Rt-Pcr; Schizophrenia Model; Sirna Downregulation Of Mrna/Protein

The goal of our project is to determine the role of two candidate schizophrenia susceptibility genes, DTNBP1 (Dystobrevin-binding protein 1/Dysbindin1) and DISC1 (Disrupted-in-schizophrenia 1), in the disruption of learning, memory, cognition, and other m

我们项目的目标是确定两个候选精神分裂症易感基因 DTNBP1（Dystobrevin 结合蛋白 1/Dysbindin1）和 DISC1（精神分裂症中断 1）在学习、记忆、认知和其他功能破坏中的作用。