Role of intrinsic versus extrinsic cues in cell type determination during development and regeneration

内在与外在线索在发育和再生过程中细胞类型决定中的作用

• 批准号: DE120101311
• 负责人: Dr Patricia Jusuf
• 金额: $ 28.61万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-10 至 2017-07-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE120101311
• 关键词: Role; intrinsic; versus; extrinsic; cues

During development all of the different cell types are generated by the action of genes and also signals from the embryo that read out which cell types are present or missing. This project studies how much environmental signals affect cell type generation developmentally and if they can be used to regenerate only the types missing in different diseases.

在发育过程中，所有不同类型的细胞都是由基因的作用和胚胎发出的信号产生的，这些信号可以读出存在或缺失的细胞类型。该项目研究环境信号在发育过程中对细胞类型产生的影响程度，以及它们是否可以用于再生不同疾病中缺失的类型。