The role of the Hsp90 system in promoting and maintaining genetic complexity

Hsp90系统在促进和维持遗传复杂性中的作用

• 批准号: 386803-2011
• 负责人: LaPointe, Paul
• 金额: $ 2.19万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=485511
• 关键词: role; Hsp90; system; promoting; maintaining

Genome sequencing projects of organisms ranging from yeast to humans have yielded an enormous amount of information regarding evolution of genes, gene families and biology as a whole. Two of the many surprises that have come from this area of research are how few genes humans have (five times fewer than had been previously predicted) and the striking degree of similarity between humans and other organisms. It has become clear that gene numbers alone cannot explain the vast array of forms present on the planet. The emerging view is that how these genes are regulated plays a much larger role in biology than previously thought.

从酵母到人类的生物体的基因组测序项目已经产生了大量关于基因、基因家族和整个生物学进化的信息。这一领域的研究令人惊讶，其中有两个是人类的基因数量之少（比先前预测的少五倍），以及人类和其他生物体之间惊人的相似程度。很明显，基因数量本身并不能解释地球上存在的大量形式。新出现的观点是，这些基因的调控方式在生物学中发挥的作用比以前想象的要大得多。