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Mucosal innate immunity in HIV resistant women

Mucosal innate immunity in HIV resistant women
艾滋病毒耐药女性的粘膜先天免疫
批准号：
237486
负责人：
Roger Michel
金额：
$20.13万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-09-01 至 2014-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=237486&lang=en
关键词：
Cell Phenotype Analysis By Flow Cytometry Cytokine/Chemokine Measurements Female Commercial Sex Workers Genital Mucosal Immunity Hiv Susceptibility/Resistance Hiv/Aids Pathogenesis

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中文摘要
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英文摘要
Most HIV infections are acquired through heterosexual intercourse, and each year the rate of HIV-infected women increases dramatically. Initial exposure to HIV-1 during sexual transmission occurs in the genital tract, however, little is known about HIV-1-
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Mucosal innate immunity in HIV resistant women
Identification of Blys/BAFF as a new therapeutic target for limiting immune activation and viral reservoirs during HIV/SIV infection
Modulation of BLyS levels to restore immune efficiency and reduce HIV targets.