The role of CD44 in bidirectional crosstalk between smooth muscle and T lymphocytes

CD44在平滑肌和T淋巴细胞双向串扰中的作用

• 批准号: 402251-2011
• 负责人: Martin, James
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=487993
• 关键词: role; CD44; bidirectional; crosstalk; between

Studies have shown that activated T cells can adhere to airway smooth muscle (ASM) cells via CD44 and integrins and induce proliferation of ASM cells. Our preliminary data indicate an important role for the epidermal growth factor receptor (EGFR) in driving this proliferation. There are several EGFR ligands, epidermal growth factor (EGF), heparin-binding epidermal growth factor (HB-EGF), amphiregulin (Areg), ß-cellulin, transforming growth factor-a (TGF- a) and epiregulin. CD4+ Th2 cells have been shown to express Areg. The EGFR ligands are present in the cell membrane in pro-forms that are released by sheddases such as the matrix metalloproteinases (MMPs). Several ligands are upregulated in CD4+ T cells in co-culture with ASM cells and the T cells are protected from apoptosis.

研究表明，活化的T细胞可以通过CD44和整合素粘附在气道平滑肌（ASM）细胞上，诱导ASM细胞增殖。我们的初步数据表明表皮生长因子受体（EGFR）在驱动这种增殖中起重要作用。EGFR配体有几种：表皮生长因子（EGF）、肝素结合表皮生长因子（HB-EGF）、双调节蛋白（Areg）、ß-纤维素蛋白、转化生长因子-a （TGF- a）和表调节蛋白。CD4+ Th2细胞表达Areg。EGFR配体以原形式存在于细胞膜中，由基质金属蛋白酶（MMPs）等酶释放。在与ASM细胞共培养的CD4+ T细胞中，一些配体上调，并保护T细胞免于凋亡。