CRFR-mediated sensitization of 5HT2A receptor signalling in anxiety and depression

CRFR 介导的 5HT2A 受体信号传导在焦虑和抑郁中的敏化

• 批准号: 238497
• 负责人: Ferguson Stephen S
• 金额: $ 61.97万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=238497&lang=en
• 关键词: Anxiety; Crf Receptor; Endocytosis; Recycling; Resensitization; Serotonin Receptor; Stress

Depression is a widespread and serious disorder that affects the daily lives of 10-15% of Canadians. There are multiple potential causes of depression, including genetic predisposition, but the majority of cases are influenced by environmental factors.

抑郁症是一种广泛而严重的疾病，影响着10-15%的加拿大人的日常生活。 抑郁症有多种潜在原因，包括遗传易感性，但大多数病例受环境因素的影响。