Molecular mechanisms of a voltage-gated potassium channel mediated suppression of an axon guidance defect in C. elegans

电压门控钾通道介导的线虫轴突引导缺陷抑制的分子机制

• 批准号: 238330
• 负责人: Culotti Joseph G
• 金额: $ 41.92万
• 依托单位: Lunenfeld-Tanenbaum Research Institute (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=238330&lang=en
• 关键词: Axon Guidance Defects; Eva-1 Receptor; Facilitation Of Unc-6/Netrin Attraction; Potassium Channel; Sax-3/Robo Receptor; Signal Transduction Mechanism; Slt-1/Slit Axon Guidance Cue; Suppression

Understanding the molecular mechanisms that prevent spinal cord regeneration will ultimately identify methods for pharmaceutical interventions that should overcome the hurdles a neuron must overcome to grow and be guided to its normal target cell or tissu

了解阻止脊髓再生的分子机制最终将确定药物干预的方法，这些方法应该克服神经元生长所必须克服的障碍，并被引导到其正常的靶细胞或组织