Genetic regulation and molecular mechanisms of TPP riboswitches. Régulation génétique et mécanismes moléculaires des riborégulateurs TPP.

TPP核糖开关的遗传调控和分子机制。

• 批准号: 239248
• 负责人: Lafontaine Daniel
• 金额: $ 48.78万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=239248&lang=en
• 关键词: Antibacterial Compounds; Biochemistry Of Nucleic Acids; Folding Mechanisms; Gene Expression Regulation; Riboswitches; Rna Folding And Dynamics; Rna-Ligand Interactions; Single-Molecule Techniques; Thiamin Pyrophosphate (Tpp)

Riboswitches are structured RNA elements typically found in the 5' untranslated regions (5'-UTR) of mRNAs, where they regulate gene expression by binding to small metabolites. A major goal of our research is to unravel the molecular mechanisms by which th

核糖开关是通常在mRNA的5'非翻译区（5'-UTR）中发现的结构化RNA元件，其中它们通过结合小代谢物来调节基因表达。我们研究的一个主要目标是揭示细胞凋亡的分子机制。