Conformational changes of the HIV-1 envelope glycoproteins: a structural/functional approach to understand the transition to the CD4-bound conformation and identify new therapeutic targets

HIV-1 包膜糖蛋白的构象变化：一种结构/功能方法，用于了解向 CD4 结合构象的转变并确定新的治疗靶点

• 批准号: 237665
• 负责人: Finzi Andrs
• 金额: $ 36.73万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=237665&lang=en
• 关键词: Env Gps Conformational Changes; Gp120; Gp120 Cd4-Bound Conformation; Gp120-Gp41 Interaction; Gp41; Hiv; Isotermal Calorimetry; New Inhibitors Of Hiv Fusion; Surface Plasmon Resonance; Viral Replication

In the absence of treatment, human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), which has already killed more than 33 million people worldwide. To be able to spread, HIV needs first to enter human cells. To do so, HIV h

如果得不到治疗，人体免疫机能丧失病毒（艾滋病毒）会导致获得性免疫机能丧失综合症（艾滋病），在全世界已造成3 300多万人死亡。 为了能够传播，艾滋病毒首先需要进入人体细胞。 为了做到这一点，艾滋病毒h