Structural and mechanistic characterization of sensor-transducer proteins BlaR1 and MecR1 in environmental sensing and subsequent antibiotic resistance in MRSA using cell-free protein expression.

使用无细胞蛋白表达对环境传感中的传感器-转导蛋白 BlaR1 和 MecR1 以及随后的 MRSA 抗生素耐药性进行结构和机制表征。

• 批准号: 242752
• 负责人: Sobhanifar Solmaz
• 金额: $ 9.83万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-10-01 至 2014-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=242752&lang=en
• 关键词: Antibiotic Resistance; Blar1; Cell-Free Protein Expression; Environmental Sensing; Mecr1; Methicillin Resistant Staphylococcus Aureus; Nmr Spectroscopy; Signal Transduction; Transmembrane Proteins; X-Ray Crystallography

Beta-lactam antibiotics are invaluable in the battle against pathogenic bacterial infection and remain most widely used. This powerful group of antibiotics acts to destroy the integrity of bacterial cell-walls, leaving bacteria highly vulnerable to cell l

β-内酰胺抗生素在对抗病原性细菌感染的战斗中是无价的，并且仍然是最广泛使用的。这组强大的抗生素可以破坏细菌细胞壁的完整性，使细菌极易受到细胞毒的伤害。