Effects of phosphorylation on the structure and interactions of the sulfonylurea receptor's nucleotide binding domains

磷酸化对磺酰脲受体核苷酸结合域结构和相互作用的影响

• 批准号: 257420
• 负责人: de Araujo Elvin D
• 金额: $ 7.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-10-01 至 2014-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=257420&lang=en
• 关键词: Abc Transporters; Fluoresence Spectroscopy; Katp Channels; Nmr Spectroscopy; Nucleotide Binding Domais; Phosphorylation; Protein Dynamics; Protein Structure; Protein-Protein Interactions; Sulfonylurea Receptors

Healthy hearts require specific levels of potassium to function properly. The amount of potassium that enters heart cells is controlled by a protein, SUR2A. Problems with this protein are responsible for a number of cardiovascular disorders, such as heart

健康的心脏需要特定水平的钾才能正常运作。进入心脏细胞的钾量由蛋白质 SUR2A 控制。这种蛋白质的问题会导致许多心血管疾病，例如心脏病